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- Title
MTHFR inhibits TRC8‐mediated HMOX1 ubiquitination and regulates ferroptosis in ovarian cancer.
- Authors
Wang, Xiang; Xu, Zhijie; Ren, Xinxin; Chen, Xi; Yi, Qiaoli; Zeng, Shuangshuang; Thakur, Abhimanyu; Gong, Zhicheng; Yan, Yuanliang
- Abstract
In MTHFR-deficient OV cells, the overexpression of HMOX1, significantly reversed the enhanced sensitivity to CDDP in OV cells by MTHFR knock-down (Figure S6H-M). Dear Editor, The study is the first to confirm that methylenetetrahydrofolate reductase (MTHFR) could inhibit HMOX1 ubiquitination degradation by competitive interaction with TRC8, followed by blocking the occurrence of ferroptosis in ovarian cancer (OV) cells, and promote the tumour cells growth. The knock-down of MTHFR promoted the combination of TRC8 and HMOX1 (Figures 3J and S7N), whereas the overexpression of MTHFR reduced this integration in MTHFR-deficient OV cells (Figures 3K and S7O). MTHFR inhibits TRC8-mediated HMOX1 ubiquitination and regulates ferroptosis in ovarian cancer.
- Subjects
UBIQUITINATION; OVARIAN cancer; METHYLENETETRAHYDROFOLATE reductase
- Publication
Clinical & Translational Medicine, 2022, Vol 12, Issue 9, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.1013