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- Title
Gene signatures from scRNA‐seq accurately quantify mast cells in biopsies in asthma.
- Authors
Jiang, Jian; Faiz, Alen; Berg, Marijn; Carpaij, Orestes A.; Vermeulen, Corneel J.; Brouwer, Sharon; Hesse, Laura; Teichmann, Sarah A.; ten Hacken, Nick H. T.; Timens, Wim; van den Berge, Maarten; Nawijn, Martijin C.
- Abstract
Gene signatures from scRNA-seq accurately quantify mast cells in biopsies in asthma Because mast cells were nearly absent in healthy subjects, we only used the scRNA-Seq data from the 6 asthma patients to generate the mast cell-specific gene list. In the 44 asthma patients taking ICS, the average mast cell gene scores were significantly lower (median = 4.45 ± 1.13) than those found in the 25 asthma patients without ICS usage (median = 5.12 ± 0.78 and I P i = .013, Mann-Whitney test) (Figure 1B).
- Subjects
MAST cells; ASTHMA; GENES; CELL analysis; MAST cell disease; MUSCLE cells
- Publication
Clinical & Experimental Allergy, 2020, Vol 50, Issue 12, p1428
- ISSN
0954-7894
- Publication type
Article
- DOI
10.1111/cea.13732