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- Title
Effects of haloperidol on sensory processing in the hippocampus during classical eyeblink conditioning.
- Authors
Sears, L. L.; Steinmetz, Joseph E.
- Abstract
Abstract The rabbit classical eyeblink conditioning paradigm was used to assess the effects of haloperidol on hippocampal function. Haloperidol disrupted hippocampal activity and conditioned responses (CRs) at low but not high conditioned stimulus (CS) intensities. The observed relationship of hippocampal activity and the CR suggested that the hippocampus encoded sensory features associated with the learned response. Sensory processing by the hippocampus appeared to be altered by haloperidol through attenuation of the ability of a CS to evoke a learned response. Results are discussed in terms of the role of the hippocampus in sensory processing and possible mechanisms for the beneficial effects of haloperidol in schizophrenia. Classical eyeblink conditioning may provide a model system for studying behavioral and biological issues relevant to the etiology and treatment of schizophrenia.
- Subjects
HIPPOCAMPUS physiology; SENSES; CONDITIONED response; SCHIZOPHRENIA
- Publication
Psychopharmacology, 1997, Vol 130, Issue 3, p254
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s002130050237