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- Title
Chemical constituents of the aerial parts of Glycyrrhiza uralensis and their inhibitory activities against PTP1B and α-glucosidase.
- Authors
Jingran Fan; Zeyuan Dong; Yi Kuang; Yanxia Zhou; Xue Qiao; Min Ye
- Abstract
In the present study, a total of 11 compounds were isolated from the aerial parts of Glycyrrhiza uralensis, including two new compounds, glycyuralin Q (1) and glycyuralin R (2), and nine known compounds, including licoriphenone (3), orobol (4), trifoliol (5), 7,2′,4′-trihydroxy-5-methoxy-3-arylcoumarin (6), 11-hydroxy-9(Z),12(Z)-octadecadienoic acid (7), 11-hydroxy-9(E), 12(E)-octadecadienoic acid (8), licoricone (9), glycyrin (10), and 2′-hydroxyformononetin (11). Structures of the new compounds were identified by 1D, 2D NMR and HR-MS data analyses. Compounds 1, 2 and 10 showed potent inhibitory activities against PTP1B, with IC50 values of 1.43, 4.71 and 3.79 μM, respectively. Compounds 2, 4 and 10 inhibited α-glucosidase with IC50 values of 13.61, 11.13 and 17.48 μM, respectively.
- Subjects
GLYCYRRHIZA; DATA analysis
- Publication
Journal of Chinese Pharmaceutical Sciences, 2020, Vol 29, Issue 5, p305
- ISSN
1003-1057
- Publication type
Article
- DOI
10.5246/jcps.2020.05.028