We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The effect of smoking on the bioavailability of metronidazole in plasma and saliva.
- Authors
Montalli, Victor Angelo; de Cassia Bergamaschi, Cristiane; Ramacciato, Juliana Cama; Nolasco, Fabiana Pinchetti; Groppo, Francisco Carlos; de Brito Jr., Rui Barbosa; Haas, Daniel A.; Motta, Rogerio Heladio Lopes
- Abstract
The article presents a study which investigates on the relation of cigarette smoking in the bioavailability of metronidazole in plasma and saliva. The study was conducted to 13 nonsmokers who received single oral dose of 750 milligrams of metronidazole and used high-performance liquid chromatography (HPLC) to quantify the concentrates of metronidazole in plasma and saliva. The study reveals reduction in plasma concentration in smokers compared nonsmokers.
- Subjects
PERIODONTAL disease diagnosis; RISK factors of periodontal disease; ACADEMIC medical centers; BIOAVAILABILITY; CHROMATOGRAPHIC analysis; DENTISTRY; CLINICAL drug trials; METRONIDAZOLE; EVALUATION of medical care; SALIVA; SMOKING; PHARMACODYNAMICS
- Publication
Journal of the American Dental Association (JADA), 2012, Vol 143, Issue 2, p149
- ISSN
0002-8177
- Publication type
Article
- DOI
10.14219/jada.archive.2012.0125