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- Title
Oral complications in a paediatric graft versus host disease (GVHD) clinic: A retrospective study.
- Authors
Emperumal, Chitra Priya; Weller, Brett; Okane, Sara; Joseph, Renita; Kharbanda, Sandhya; Ling, Zhan; Villa, Alessandro
- Abstract
Objective: The aim of this study was to investigate the oral health status among allogeneic transplant recipients who were seen in a multidisciplinary graft‐versus‐host disease paediatric clinic at the University of California, San Francisco (UCSF). Methods: This was a retrospective cohort study of patients who underwent allogeneic transplants and were seen in the graft‐versus‐host disease paediatric clinic between January 2010 and September 2021. Demographic, medical and oral health data were recorded and analysed using descriptive statistics. Results: A total of 25 patients were seen in the paediatric graft‐versus‐host disease clinic (68% males) with a median age of 12 years at the time of transplant were included. Among them, 12 patients (48%) were diagnosed with oral chronic GVHD, 11 (44%) with dry mouth, four (16%) with oral pseudomembranous candidiasis, one (4%) with recrudescent Herpes Simplex Virus (HSV) infection and one (4%) with mammalian target of rapamycin‐inhibitor stomatitis and were managed by the oral medicine team, accordingly with medications, such as topical steroids (44%) and anti‐fungal (20%). Conclusions: HSCT recipients may present with a variety of oral complications. Patients may benefit by a multi‐disciplinary approach including a dental specialist as part of the cancer care team.
- Subjects
CALIFORNIA; STEROID drugs; GRAFT versus host disease; STOMATITIS; CUTANEOUS therapeutics; ANTIFUNGAL agents; HEALTH status indicators; PATIENTS; TRANSPLANTATION of organs, tissues, etc.; ORAL manifestations of general diseases; UNIVERSITIES &; colleges; HERPESVIRUSES; CHILDREN'S hospitals; RETROSPECTIVE studies; DESCRIPTIVE statistics; LONGITUDINAL method; ORAL medicine; MEDICAL records; ACQUISITION of data; BONE marrow transplantation; PSEUDOMEMBRANOUS enterocolitis; CANDIDIASIS; HEALTH care teams; ORAL health; RAPAMYCIN
- Publication
Oral Diseases, 2024, Vol 30, Issue 3, p1084
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.14535