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- Title
Association of plasma high-density lipoprotein cholesterol level with risk of stress urinary incontinence in women: a retrospective study.
- Authors
Xu, Wenning; Zheng, Baojia; Su, Lili; Xiang, Yali
- Abstract
Background: Studies have found that high density lipoprotein cholesterol (HDL-C) levels are linked to a variety of diseases. However, evidence for the relationship between stress urinary incontinence (SUI) and HDL-C remain limited. Methods: 590 eligible women were enrolled. Basic characteristic, gynecological examinations and blood sampling were collected. The examination of the possible link between HDL-C and SUI was done using univariate and multivariate logistic regression. Feature importance ranking and Receiver operating characteristic (ROC) curves were performed to further evaluate the association between HDL-C and SUI in women. Results: A significant association was found between HDL-C and SUI in women, revealing higher HDL-C levels were related to a lower risk of SUI (OR 0.238; 95%CI: 0.091–0.623; P < 0.01) after adjustment for potential key confounders. The AUC for the SUI predicted by the combined HDL-C was 0.845 (95%CI: 0.798–0.891, P < 0.001). The feature importance ranking revealed that vaginal delivery, HDL-C were the top two important factors. Conclusions: HDL-C levels were correlated with the development of SUI. In addition to physical and surgical treatments, HDL-C may offer the possibility of potential targeted treatment and prevention of SUI afterwards.
- Subjects
URINARY stress incontinence; HDL cholesterol; URINARY incontinence in women; HIGH density lipoproteins; DELIVERY (Obstetrics); RECEIVER operating characteristic curves; CHOLESTEROL
- Publication
Lipids in Health & Disease, 2024, Vol 23, Issue 1, p1
- ISSN
1476-511X
- Publication type
Article
- DOI
10.1186/s12944-024-02137-6