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- Title
Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum.
- Authors
Wang, Hui-Chun; Ke, Tzu-Yi; Ko, Ya-Chen; Lin, Jue-Jun; Chang, Jui-Sheng; Cheng, Yuan-Bin
- Abstract
To discover the new medical entity from edible marine algae, our continuously natural product investigation focused on endophytes from marine macroalgae Grateloupia sp. Two new azaphilones, 8a-epi-hypocrellone A (1), 8a-epi-eupenicilazaphilone C (2), together with five known azaphilones, hypocrellone A (3), eupenicilazaphilone C (4), ((1E,3E)-3,5-dimethylhepta-1,3-dien-1-yl)-2,4-dihydroxy-3-methylbenzaldehyde (5), sclerotiorin (6), and isochromophilone IV (7) were isolated from the alga-derived fungus Penicillium sclerotiorum. The structures of isolated azaphilones (1–7) were elucidated by spectrometric identification, especially HRESIMS, CD, and NMR data analyses. Concerning bioactivity, cytotoxic, anti-inflammatory, and anti-fibrosis activities of those isolates were evaluated. As a result, compound 1 showed selective toxicity toward neuroblastoma cell line SH-SY5Y among seven cancer and one fibroblast cell lines. 20 μM of compounds 1, 3, and 7 inhibited the TNF-α-induced NFκB phosphorylation but did not change the NFκB activity. Compounds 2 and 6 respectively promoted and inhibited SMAD-mediated transcriptional activities stimulated by TGF-β.
- Subjects
EDIBLE fungi; MARINE algae as food; PENICILLIUM; SCLEROTINIA sclerotiorum; CELL lines; NATURAL products; PHOSPHORYLATION; FIBROBLASTS
- Publication
Marine Drugs, 2021, Vol 19, Issue 10, p529
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md19100529