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- Title
Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy.
- Authors
Mohabati, Danial; Dijk, Elon HC van; Rijssen, Thomas J van; Jong, Eiko K de; Breukink, Myrte B; Martinez-Ciriano, Jose P; Dijkman, Greet; Hoyng, Carel B; Fauser, Sascha; Yzer, Suzanne; Boon, Camiel JF
- Abstract
Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT).Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures.Results: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple "hot spots" of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (P<0.001), and from 78 to 82 ETDRS letters in the control group (P<0.001). SRF had resolved completely in 87% of severe cCSC cases and 95% of controls at final follow-up visit.Conclusion: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment.
- Subjects
RETINAL diseases; PHOTODYNAMIC therapy; VISUAL acuity; RHODOPSIN; RETINAL degeneration
- Publication
Clinical Ophthalmology, 2018, Vol 12, p2167
- ISSN
1177-5467
- Publication type
Article
- DOI
10.2147/OPTH.S174573