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- Title
Proximal shift of colorectal cancer with increasing age in different ethnicities.
- Authors
Yang, Lin; Xiong, Zhenchong; He, Wenzhuo; Xie, Kunqian; Liu, Shousheng; Kong, Pengfei; Jiang, Chang; Guo, Guifang; Xia, Liangping
- Abstract
Background: Studies have indicated a variation in colon cancer pathology with increased age. More findings have also suggested differences in genetics, biology, and demography in terms of ethnicity. Large-scale studies closely examining tumor location shift with aging and ethnicity are scarce. Objective: We compared the tumor location shift with aging and the difference in survival based on tumor location by age group among the African-American, White, and Asian/Pacific Islander patients with colorectal cancer. Materials and methods: We collected 270,390 cases from the Surveillance, Epidemiology, and End Results database between 2004 and 2014. Ethnicity distribution between younger (age <70 years) and older (age ≥70 years) patients was analyzed using univariate and multivariate logistic regression. The Kaplan–Meier method was used to compare the tumor location survival difference in the African-American, White, and Asian/Pacific Islander patients. Results: Larger tumors, female sex, M0, advanced N stage, no treatment, moderate to poor differentiation, total number of lymph nodes evaluated >12, and right-sided colon cancer were more common in patients aged ≥70 years. More adverse prognosis was found in younger patients compared to older patients. Tumor location frequency differed based on age; the most pronounced differences were found in White patients. The right-sided colon cancer survival inferiority was present only in White patients. Conclusion: Our findings support the premise of etiological and carcinogenic differences based on tumor location and between younger and older patients.
- Subjects
GENETICS of colon cancer; COLON cancer prognosis; COLON cancer patients; CANCER pathophysiology; ETIOLOGY of cancer
- Publication
Cancer Management & Research, 2018, Vol 10, p2663
- ISSN
1179-1322
- Publication type
Article
- DOI
10.2147/CMAR.S166548