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- Title
BIOLOGY OF AORTIC ANEURYSMS AND DISSECTIONS.
- Authors
Fernandez-Moure, Joseph S.; Vykoukal, Daynene; Davies, Mark G.
- Abstract
The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predeterminants are influenced by smoking, hypertension, and atherosclerosis, and the result is an inflammatory response coupled to an accelerated proteolytic cascade that disrupts both elastin and collagen in the aortic wall.
- Subjects
AORTIC aneurysms; DISSECTION; EXTRACELLULAR matrix proteins; SMOOTH muscle; GROWTH factors; HOMEOSTASIS; HYPERTENSION; ATHEROSCLEROSIS
- Publication
Methodist DeBakey Cardiovascular Journal, 2011, Vol 7, Issue 3, p2
- ISSN
1947-6094
- Publication type
Article
- DOI
10.14797/mdcj-7-3-2