We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Catalytic Continuous Reductive Amination with Hydrogen in Flow Reactors.
- Authors
Zhang, Jiahao; Xu, Yanlin; Li, Yingying; Yin, Jiabin; Zhang, Jisong
- Abstract
Reductive amination with hydrogen is a green and atom‐efficient method to construct amines from accessible aldehydes and ketones. Flow reactors, with superior mass and heat transfer rate because of higher specific surface area, have emerged as a powerful tool to conduct reductive amination with high efficiency and selectivity. This article discusses the influence of catalysts, solvents, temperatures, additives, and substrate properties on reductive amination. Following this, a summary of research on reductive amination with hydrogen in flow reactors is provided. The investigations were classified based on distinct nitrogen sources, encompassing the use of ammonia, amines, and nitro compounds. Based on the influencing factors and reaction cases, the article analyzes the enhancement effects of temperature control, mass transfer intensification, and residence time distribution in flow reactors on the reductive amination. Finally, the article gives a conclusion by addressing challenges and prospects for further developments in this field.
- Subjects
AMINATION; GREEN fuels; TEMPERATURE control; MASS transfer; NITRO compounds; HYDROGEN
- Publication
ChemCatChem, 2024, Vol 16, Issue 11, p1
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.202301521