We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Preparation of Amphiphilic B-Cyclodextrin Nanoparticles by Solvent Evaporation Method Influence of the Surfactant on Preparation and Hydrophobic Drug Loading.
- Authors
Haran, D. Hari; Kumar, M. Ashok; Dinesh, S.; Mohan, M.; Sujith, A. Nirmal; Raghunath, G.; Rao, Ch. V. Srinivas; Dey, Suddhasattya
- Abstract
The present study behind this work is to find to prepare amphiphilic β cyclodextrin nanoparticles by solvent evaporation methods, Influence of surfactant on preparation and hydrophobic drug loading. First of all to formulate irinotecan nanoparticles using the β cyclodextrin under various ratios's like 1:1, 1:2, 1:3 with the surfactant poloxamer. This irinotecan nanoparticle was prepered by using β cyclodextrin which were prepared by emulsification solvent evaporation method. Three batches were made in various concentrations of β cyclodextrin is used by keeping the drug as constant. Then evaluation of irinotecan hydrochloride nanoparticles was carried out for characteristics like entrapment efficacy (drug release profile), UV analysis. In vitro release starts from 15 min and up to 16 hrs. It shows the percentage of gradual drug release as 1.3%, 1.7%, 1.21%, 1.6%, 2.26%, 3.1%, 3.9%, 6.16%, 6.3%, 6.36%, against the label claim as 20mg/ml. At 16th hrs there is a decline in % of drug release from 6.36% to 5.75%.
- Subjects
AMPHIPHILES; CYCLODEXTRINS; SURFACE active agents; HYDROPHOBIC compounds; STABILIZING agents; HYDROCHLORIC acid
- Publication
Drug Invention Today, 2011, Vol 3, Issue 9, p216
- ISSN
0975-7619
- Publication type
Article