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- Title
Antibacterial and Antineoplastic Effect of Root of Euphorbia hirta L.
- Authors
Khandoker, A. K. M. Zakir Hossain; Habib, M. Rowshanul; Nikkon, Farjana; Rahman, Matiar; Karim, M. Rezaul
- Abstract
This dissertation describes the antibacterial and antineoplastic effect (against Ehrlich's Ascites Carcinoma; EAC) of methanol extract of root of Euphorbia hirta L. Methanol extract showed moderate activity against both Gram positive (Staphylococcus aureus, Bacillus subtilis, and Bacillus megaterium) and Gram negative (Escherchia coli, Shigella dysenteriae and Shigella sonnei) bacteria. In vivo the root extract resulted 45% and 54.4% Ehrlich's Ascites Carcinoma (EAC) cell growth inhibition at the dose of 10 and 20 mg/kg body weight, respectively. The root extract also showed moderate cytotoxic effect (LC50 37.07 μg.ml-1) against Artemia salina (brine shrimp nauplii) in respect to ampicillin trihydrate (LC50 16.87 μg.ml-1).
- Subjects
BANGLADESH; EUPHORBIA; HERBAL medicine; EHRLICHIOSIS; ANTIBACTERIAL agents; ANTI-infective agents; ANTINEOPLASTIC agents; STAPHYLOCOCCUS aureus; SHIGELLA; THERAPEUTICS
- Publication
Drug Invention Today, 2009, Vol 1, Issue 1, p10
- ISSN
0975-7619
- Publication type
Article