We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Preoperative leukocyte count and postoperative inpatient mortality in South African non-cardiac surgery patients.
- Authors
Abbas, Nafisa; Moodley, Yoshan
- Abstract
Background: Published studies investigating the relationship between preoperative leukocyte counts and postoperative inpatient mortality in South African (SA) non-cardiac surgery settings are scarce. This could have important implications for perioperative risk stratification in SA non-cardiac surgery settings. The aim of our study was to address this paucity in the literature. Methods: We conducted an unmatched case-control study of patient data from the South African Surgical Outcomes Study. Data collected for each patient included demographic variables, comorbidities, procedure-related variables, and preoperative laboratory test results (including leukocyte counts). Local reference ranges were used to stratify preoperative leukocyte count into three categories: normal, leukocytopenia, and leukocytosis. The sample size for this study was 495 patients (case:control ratio of 1:3). Data were analyzed using appropriate univariate and multivariate statistical methods. Results: Preoperative leukocytosis was associated with increased postoperative inpatient mortality (odds ratio: 1.95, 95% confidence interval: 1.05-3.63; p=0.034). Preoperative leukocytopenia was not associated with postoperative inpatient mortality (odds ratio: 0.40, 95% confidence interval: 0.05-3.40; p=0.400). Conclusion: Preoperative leukocytosis is a risk factor for postoperative inpatient mortality in SA non-cardiac surgery patients. Studies evaluating the prognostic accuracy of preoperative leukocytosis for postoperative mortality in SA non-cardiac surgery settings are required.
- Subjects
SOUTH Africa; CONFIDENCE intervals; LEUCOCYTE disorders; LEUCOPENIA; MULTIVARIATE analysis; PATIENTS; RISK assessment; STATISTICS; SURGERY; SURGICAL complications; CASE-control method; PREOPERATIVE period; HOSPITAL mortality; LEUKOCYTE count; ODDS ratio; DISEASE complications
- Publication
University of Toronto Medical Journal, 2019, Vol 96, Issue 1, p10
- ISSN
0833-2207
- Publication type
Article