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- Title
Intravenous paracetamol in pediatrics: A global perspective.
- Authors
Irshad, Muzammil; Malik, Mehjabeen; Furqan, Aamir
- Abstract
Intravenous (IV) Paracetamol is an excellent post operative analgesic and antipyretic in children. Efficacy and tolerability of IV Propacetamol have been established in pediatric practice. It is believed that paracetamol works by inhibiting cyclooxygenase-2 (COX-2) enzymes. Studies bring to light that therapeutic doses of IV acetaminophen are effective and tolerable in children with least chances of hepatotoxicity. However, overdose toxicity has been reported in children and drug induced hypotension in febrile critically ill patients. Therapeutic doses according to body weight of neonates and children can be administered in hospital settings. Special education of health care staff regarding precise dose and solution is necessary to assess the role of IV paracetamol preparation in pediatric practice.
- Subjects
ACETAMINOPHEN; INTRAVENOUS therapy; PHYSIOLOGICAL effects of analgesics; DRUG efficacy; CYCLOOXYGENASE 2
- Publication
Anaesthesia, Pain & Intensive Care, 2012, Vol 16, Issue 3, p311
- ISSN
1607-8322
- Publication type
Article