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- Title
Hiyaluronik asit/karboksimetil selüloz bariyer uygulamasının yapışıklıklar ve Hartmann kolostomisinin kapatılmasından sonra anastomoz iyileşmesi üzerine etkileri.
- Authors
Demirkiran, Ahmet Ender; Erpek, Hakan; Çakır, Cumhur; Kozacı, Didem; Tunçyürek, Pars
- Abstract
Background: Adhesion formation is one of the leading causes of morbidity after abdominal surgery. In this study, it is aimed to investigate effects of anti-adhesive hyaluronic acid/carboxymethylcellulose membrane on adhesions and anastomotic healing after Hartmann colostomy closure in a rat model. Materials and Methods: Thirty male Wistar-Albino rats are randomised into 3 groups: Standard colostomy (Grup A), standart colostomy + hyaluronic acid/carboxymethylcellulose (Grup B), and control group (Grup C). Adhesions were evaluated by means of a scoring system. Bursting pressure values, and hydroxyproline levels were detected. Results: Adhesion score of group A (1.7±0.6) was statistically higher compared to group B (1.1±0.3), and to control group C (1.2±0.4) (p<0.05). There was no statistical difference between bursting pressure values, and hydroxyproline levels. Conclusions: Although hyaluronic acid/carboxymethylcellulose membrane decreased adhesion formation, there was no obvious effect on anastomotic strength and healing. On the other hand, further clinical studies are needed to draw major conclusions.
- Subjects
HYALURONIC acid; MUCOPOLYSACCHARIDES; ORGANIC acids; ADHESION; COLOSTOMY; COLON surgery; ENTEROSTOMY; ADSORPTION (Chemistry); SURGICAL complications
- Publication
Turkish Journal of Surgery / Ulusal Cerrahi Dergisi, 2009, Vol 25, Issue 1, p15
- ISSN
1300-0705
- Publication type
Article