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- Title
Factors for progression of periodontal diseases.
- Authors
Ellis, S. O.; Tuccl, M. A.; Serio, F. G.; Johnson, A. B.; Ellis, S D; Tucci, M A; Johnson, R B
- Abstract
Progression factors for periodontal diseases have been suggested by <em>in vitro</em> study of peripheral blood and gingival cells however, those factors are not established <em>in vitro</em>. This investigation assessed biopsies of three groups of gingival tissues those adjacent to a D <3 mm (normal), 2) 4 6 mm. and 3) >6 mm gingival sulcus, to determine changes in the gingival microenvironment coincident to progression periodontal disease. Superoxide dismutase (SOD) and catalase activity, and IL-12 and bel-2 levels, were decreased at >6 mm; total protein and IL-6 concentrations were increased adjacent to >6 mm, as compared to &les; and 4.6 mm, sites. Apoptotic cells were evident only within gingiva adjacent to >6 mm sites. These data suggest that IL-12 is an important factor in the shift from a TH1 to TH2 cell profile and that a favorable gingival microenvironment for hyper-inflammation may develop coincident to progression of periodontal diseases due to decreased bel-2 and increased IL-6 concentrations within gingiva. These changes in the gingival microenvironment could impair apoptosis and promote enhanced release of reactive oxygen species (ROS) by phagocytes: decreased catalase and SOD activity could promote accumulation of ROS and result in additional tissue destruction.
- Subjects
PERIODONTAL disease; SUPEROXIDE dismutase; REACTIVE oxygen species; APOPTOSIS; PHAGOCYTES; CATALASE
- Publication
Journal of Oral Pathology & Medicine, 1998, Vol 27, Issue 3, p101
- ISSN
0904-2512
- Publication type
journal article
- DOI
10.1111/j.1600-0714.1998.tb01923.x