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- Title
Increased production of tumour necrosis factor by peripheral blood leukocytes in patients with recurrent oral aphthous ulceration.
- Authors
Taylor, Lisa J.; Bagg, Jeremy; Walker, D. Murray; Peters, Timothy J.; Taylor, L J; Bagg, J; Walker, D M; Peters, T J
- Abstract
Much evidence suggests that recurrent oral aphthous ulceration (RAU) is an immunologically mediated disease. Tomour necrosis factor has multiple biologic properties, some of which may be relevant to the pathogenesis of RAU. This study has assessed its production by peripheral blood leukocytes from aphthous patients in active remission phases of disease and from patients with non- aphthous ulceration (diseased controls). Each ulcer patients was studied in parallel with a matched healthy control volunteer. A bioassay against the standard mouse fibrosarcoma line, L929 , was used to assess the levels of tumour necrosis factor-α (TNF). Significantly greater amounts of TNF were released from unstimulated monocyte-enriched and monocyte-depleted leukocyte fractions in active RAU compared with those form healthy control donors, suggesting that this cytokine may be associated with RAU.
- Subjects
MOUTH ulcers; TUMOR necrosis factors; LEUCOCYTES; GROWTH factors; LYMPHOCYTE metabolism; ENDOTOXINS; ESCHERICHIA coli; MONOCYTES; ORAL diseases; DISEASE relapse; CASE-control method; CANKER sores; LIPOPOLYSACCHARIDES
- Publication
Journal of Oral Pathology & Medicine, 1992, Vol 21, Issue 1, p21
- ISSN
0904-2512
- Publication type
journal article
- DOI
10.1111/j.1600-0714.1992.tb00963.x