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- Title
A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole.
- Authors
Tebben, Jan; Motti, Cherie; Tapiolas, Dianne; Thomas-Hall, Peter; Harder, Tilmann
- Abstract
The ethanol extract of Pseudoalteromonas strain J010, isolated from the surface of the crustose coralline alga Neogoniolithon fosliei, yielded thirteen natural products. These included a new bromopyrrole, 4'-((3,4,5-tribromo-1H-pyrrol-2-yl) methyl)phenol (1) and five new korormicins G-K (2-6). Also isolated was the known inducer of coral larval metamorphosis, tetrabromopyrrole (TBP), five known korormicins (A-E, previously named 1, 1a-c and 3) and bromoalterochromide A (BAC-A). Structures of the new compounds were elucidated through interpretation of spectra obtained after extensive NMR and MS investigations and comparison with literature values. The antibacterial, antifungal and antiprotozoal potential of 1-6, TBP and BAC-A was assessed. Compounds 1-6 showed antibacterial activity while BAC-A exhibited antiprotozoal properties against Tetrahymena pyriformis. TBP was found to have broad-spectrum activity against all bacteria, the protozoan and the fungus Candida albicans.
- Subjects
CORALLINE algae; GRAM-negative bacteria; PYRROLES; ANTIBIOTICS; CANDIDA albicans; MARINE bacteria; ETHANOL
- Publication
Marine Drugs, 2014, Vol 12, Issue 5, p2802
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md12052802