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- Title
Antimalarial Activity of Axidjiferosides, New ß-Galactosylceramides from the African Sponge Axinyssa djiferi.
- Authors
Farokhi, Fereshteh; Grellier, Philippe; Clément, Monique; Roussakis, Christos; Loiseau, Philippe M.; Genin-Seward, Emilie; Kornprobst, Jean-Michel; Barnathan, Gilles; Wielgosz-Collin, Gaëtane
- Abstract
The marine sponge, Axinyssa djiferi, collected on mangrove tree roots in Senegal, was investigated for glycolipids. A mixture containing new glycosphingolipids, named axidjiferoside-A, -B and -C, accounted for 0.07% of sponge biomass (dry weight) and for 2.16% of total lipids. It showed a significant antimalarial activity, with a 50% inhibitory concentration (IC50) of 0.53 ± 0.2 µM against a chloroquine-resistant strain of Plasmodium falciparum. They were identified as homologous ß-galactopyranosylceramides composed of 2-amino-(6E)-octadec-6-en-1,3,4-triol, and the major one, axidjiferoside-A (around 60%), contained 2-hydroxytetracosanoic acid. Cytotoxicity was studied in vitro on human cancer cell lines (multiple myeloma, colorectal adenocarcinoma, glioblastoma and two lung cancer NSCLC-N6 and A549). Results of this investigation showed that axidjiferosides are of interest, because they proved a good antiplasmodial activity, with only a low cytotoxicity against various human cell lines and no significant antitrypanosomal and antileishmanial activity. Thus, it seems that galactosylceramides with a ß anomeric configuration may be suitable in searching for new antimalarial drugs.
- Subjects
ANTIMALARIALS; GALACTOSYLCERAMIDES; SPONGES (Invertebrates); MARINE metabolites; CANCER cells; CELL-mediated cytotoxicity
- Publication
Marine Drugs, 2013, Vol 11, Issue 4, p1304
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md11041304