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- Title
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.
- Authors
Wang, Zack Z; Au, Patrick; Tong Chen; Ying Shao; Daheron, Laurence M; Hao Bai; Arzigian, Melanie; Fukumura, Dai; Jain, Rakesh K; Scadden, David T
- Abstract
We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.
- Subjects
EMBRYONIC stem cells; ENDOTHELIUM; TRANSPLANTATION of organs, tissues, etc.; IMMUNODEFICIENCY; MICE
- Publication
Nature Biotechnology, 2007, Vol 25, Issue 3, p317
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt1287