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- Title
Editing the message from A to I.
- Authors
Nishikura, Kazuko
- Abstract
The article discusses about the biological significance of RNA editing. Numerous adenosine-to-inosine editing sites found in mRNA sequences raise new questions about the importance of RNA editing. One type of RNA editing involves the conversion of adenosine (A) residues into inosine (I) residues through an action of adenosine deaminases acting on RNA. The substrate for A-to-I RNA editing is a double-stranded RNA (dsRNA), typically an imperfectly base-paired pre-mRNA duplex that forms between an exon sequence harboring the editing site and a nearby intorn sequence. Association of A-to-I RNA editing with repetitive sequences is likely to extend even to invertebrate transcriptomes.
- Subjects
RNA editing; ADENOSINE deaminase; DOUBLE-stranded RNA; MESSENGER RNA; INOSINE; GENETIC regulation; ADENOSINES; INVERTEBRATES
- Publication
Nature Biotechnology, 2004, Vol 22, Issue 8, p962
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt0804-962