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- Title
The genome sequence of the extreme thermophile Thermus thermophilus.
- Authors
Henne, Anke; Brüggemann, Holger; Raasch, Carsten; Wiezer, Arnim; Hartsch, Thomas; Liesegang, Heiko; Johann, Andre; Lienard, Tanja; Gohl, Olivia; Martinez-Arias, Rosa; Jacobi, Carsten; Starkuviene, Vytaute; Schlenczeck, Silke; Dencker, Silke; Huber, Robert; Klend, Hans-Peter; Kramer, Wilfried; Merkl, Rainer; Gottschalk, Gerhard; Fritz, Hans-Joachim
- Abstract
<em>Thermus thermophilus</em> HB27 is an extremely thermophilic, halotolerant bacterium, which was originally isolated from a natural thermal environment in Japan. This organism has considerable biotechnological potential; many thermostable proteins isolated from members of the genus <em>Thermus</em> are indispensable in research and in industrial applications. We present here the complete genome sequence of <em>T. thermophilus</em> HB27, the first for the genus <em>Thermus</em>. The genome consists of a 1,894,877 base pair chromosome and a 232,605 base pair megaplasmid, designated pTT27. The 2,218 identified putative genes were compared to those of the closest relative sequenced so far, the mesophilic bacterium <em>Deinococcus radiodurans</em>. Both organisms share a similar set of proteins, although their genomes lack extensive synteny. Many new genes of potential interest for biotechnological applications were found in <em>T. thermophilus</em> HB27. Candidates include various proteases and key enzymes of other fundamental biological processes such as DNA replication, DNA repair and RNA maturation.
- Subjects
GENOMES; THERMOPHILIC bacteria; PROTEINS; CHROMOSOMES; DNA repair; DNA replication; RNA
- Publication
Nature Biotechnology, 2004, Vol 22, Issue 5, p547
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt956