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- Title
Four 'lessons learned' while implementing a multi-site caries prevention trial.
- Authors
Bader, James D.; Robinson, Debbie S.; Gilbert, Gregg H.; Ritter, Andre V.; Makhija, Sonia K.; Funkhouser, Kimberly A.; Amaechi, Bennett T.; Shugars, Daniel A.; Laws, Reesa
- Abstract
As the number of dental-related randomized clinical trials (RCTs) increases, there is a need for literature to help investigators inexperienced in conducting RCTs design and implement studies. This commentary describes four 'lessons learned' or considerations important in the planning and initial implementation of RCTs in dentistry that, to our knowledge, have not been discussed in the general dental literature describing trial techniques. These considerations are a) preparing or securing a thorough systematic review; b) developing a comprehensive set of study documents; c) designing and testing multiple recruitment strategies; and d) employing a run-in period prior to enrollment. Attention to these considerations in the planning phases of a dental RCT can help ensure that the trial is clinically relevant while also maximizing the likelihood that its implementation will be successful.
- Subjects
UNITED States; PROCEDURE manuals; RANDOMIZED controlled trials; PATIENT selection; SYSTEMATIC reviews; CLINICAL trials; CAVITY prevention; NATIONAL Institute of Dental &; Craniofacial Research (U.S.)
- Publication
Journal of Public Health Dentistry, 2010, Vol 70, Issue 3, p171
- ISSN
0022-4006
- Publication type
Article
- DOI
10.1111/j.1752-7325.2010.00167.x