We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat.
- Authors
Bouaziz, Amel; Khennouf, Seddik; Zarga, Musa Abu; Abdalla, Shtaywy
- Abstract
The objective of this study was to evaluate the in vitro anti-oxidant, hypotensive and the diuretic activities of Origanum glandulosum leaves in rat. Chemical analysis revealed the isolation of katuranin and 5-isopropyl-3- methylphenol. Ethyl acetate extract possessed highest scavenging activity against DPPH and hydroxyl radicals. Intravenous administration of extracts (0.04 to 12 mg/kg body weight) dose-dependently decreased the blood pressure (systolic, diastolic and mean) of the anesthetized rat. Methanol extract showed dose-dependent diuretic activity by increasing the urine output (77%) and the urinary excretion of sodium and potassium. In conclusion, this study supports the use of O. glansulosum in traditional medicine as hypotensive and diuretic agents.
- Subjects
ETHYL acetate; OREGANO; RATS; ANTIHYPERTENSIVE agents; HYDROXYL group; INTRAVENOUS therapy
- Publication
Bangladesh Journal of Pharmacology, 2019, Vol 14, Issue 1, p17
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v14i1.38089