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- Title
Increased IL17A, IFNG, and FOXP3 Transcripts in Moderate-Severe Psoriasis: A Major Influence Exerted by IL17A in Disease Severity.
- Authors
Oliveira, Priscilla Stela Santana de; Pereira, Michelly Cristiny; Silva de Paula, Simão Kalebe; Lima, Emerson Vasconcelos Andrade; Lima, Mariana Modesto de Andrade; Arruda, Rodrigo Gomes de; Oliveira, Wagner Luís Mendes de; Duarte, Ângela Luzia Branco Pinto; Pitta, Ivan da Rocha; Rêgo, Moacyr Jesus Melo Barreto; Galdino da Rocha Pitta, Maira
- Abstract
Psoriasis is a chronic and recurrent dermatitis, mediated by keratinocytes and T cells. Several proinflammatory cytokines contribute to formation and maintenance of psoriatic plaque. The Th1/Th17 pathways and some of IL-1 family members were involved in psoriasis pathogenesis and could contribute to disease activity. Therefore, we sought to analyse skin transcript levels of IL17A, IL22, RORC, IL8, IFNG, IL33, IL36A, FOXP3, and IL10 and correlate with clinic of patients with plaque-type psoriasis. In order to conduct that, we collected punch biopsies from lesional skin and obtained tissue RNA. After reverse transcription, qRT-PCR quantified the relative mRNA expression. The main results revealed increased transcripts levels of IL17A, IFNG, and FOXP3 in moderate-severe patients. Despite this, only IL17A can increase the chance to worsen disease severity. We also observed many significant positive correlations between each transcript. In conclusion, IL17A is elevated in lesional skin from psoriasis patients and plays crucial role in disease severity.
- Subjects
PSORIASIS; INTERLEUKIN-17; INTERFERON gamma; FORKHEAD transcription factors; KERATINOCYTES; SEVERITY of illness index
- Publication
Mediators of Inflammation, 2016, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/2016/4395276