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- Title
A Polymorphism in the Interleukin-1α Gene Influences the Clinical Features of Migraine.
- Authors
Rainero, Innocenzo; Pinessi, Lorenzo; Salani, Giuliana; Valfrè, Walter; Rivoiro, Chiara; Savi, Lidia; Gentile, Salvatore; Giudice, Rossana Lo; Grimaldi, Luigi M.E
- Abstract
Objective.—To evaluate whether a particular genotype of the interleukin-1α (IL1A ) gene affects the clinical features of migraine. Background.—Proinflammatory mediators have been reported to play a role in the pathophysiology of migraine. Recent studies suggest that polymorphisms in the interleukin-1 genes influence the age at onset and subsequent course of several chronic inflammatory diseases. Methods.—In a group of 269 patients with migraine, we tested the association of the -889 C/T biallelic polymorphism of the IL1A gene with several clinical features of the disease. Results.—Patients with migraine carrying the T/T genotype show an age at onset of the disease that is significantly (P < .01) lower than IL1A C/C or C/T carriers. In addition, the same genotype was significantly (P < .05) more frequent in patients with migraine with aura than in patients with migraine without aura. Conclusions.—The results of our study suggest a role for the IL1A gene in modifying the clinical features of migraine.
- Subjects
INTERLEUKIN-1; MIGRAINE; GENETICS
- Publication
Headache: The Journal of Head & Face Pain, 2002, Vol 42, Issue 5, p337
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1046/j.1526-4610.2002.02103.x