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- Title
Common Variable Immunodeficiency with Increased Surface IgM-Positive Double-Bearing B Cells.
- Authors
Motoyoshi, F.; Mori, S.; Kondo, N.; Kaneko, H.; Ozawa, T.; Kuwabara, N.; Kato, Y.; Takemura, M.; Noma, A.; Orii, T.
- Abstract
We report a case of common variable immunodeficiency (CVI) that shows low levels of IgG and IgA, but a normal quantitative or qualitative level of IgM. T-cell functions were not disturbed. Increased numbers of surface IgM (sIgM) and sIgD, sIgM and sIgG, sIgM and sIgA double-bearing B cells were observed as compared with a control. No IgG and IgA induction upon stimulation with Staphylococcus aureus Cowan I (SAC) and recombinant interleukin-2 (rIL-2), or pokeweed mitogen (PWM) and rIL-4 or rIL-6 was observed, although there was proliferation. Although μmRNA was expressed as much as in a healthy control, transcription of γ mRNA and a mRNA was very low. Furthermore, no enhanced effects of γ mRNA and α mRNA were recognized upon stimulation with rIL-4 and rIL-6. These results suggest that the patient's B cells might be defective at the switching process from μ, μ and δ, μ and γ to γ or μ and α to α.
- Subjects
IMMUNODEFICIENCY; IMMUNOGLOBULIN M; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; B cells; ANTIGEN presenting cells; LYMPHOCYTES
- Publication
Scandinavian Journal of Immunology, 1992, Vol 36, Issue 1, p21
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1992.tb02936.x