We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expression of tissue inhibitor of metalloproteinases-1 and B-cell lymphoma-2 in the synovial membrane in patients with knee osteoarthritis.
- Authors
Li, Xiaomiao; Fu, Xiaodong; Gao, Yingjian; Li, Hao; Wang, Weili; Shen, Yi
- Abstract
The purpose of this study was to determine the expression and impact of tissue inhibitor of metalloproteinases- 1 (TIMP-1) and B-cell lymphoma-2 (Bcl-2) in knee osteoarthritis (KOA). We collected synovial fluids from the knee joint of 70 KOA patients and 30 controls. The expression levels of TIMP-1 and Bcl-2 were significantly higher in KOA patients than those in the control group (P<0.01). We also found positive correlation between the severity of KOA and the expression level of TIMP-1 (r=0.8027, P<0.05) and and Bcl-2 (r=0.5336, P<0.05). However, we found no correlation between the expression levels of TIMP-1 and Bcl-2 in the synovial membranes of KOA patients (P>0.05). Both TIMP-1 and Bcl-2 are expressed at high levels in the synovial membrane with KOA, and are closely related to the occurrence and development of KOA. Thus, detection of TIMP-1 and Bcl-2 in KOA patients can be helpful in diagnosing the state of KOA.
- Subjects
GENE expression; TISSUE inhibitors of metalloproteinases; BCL-2 proteins; OSTEOARTHRITIS; SYNOVIAL membranes; BONE spurs; PATIENTS
- Publication
Experimental & Therapeutic Medicine, 2018, Vol 15, Issue 1, p885
- ISSN
1792-0981
- Publication type
Article
- DOI
10.3892/etm.2017.5462