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- Title
Linkage mapping of sex-specific differences.
- Authors
WU, RONGLING; MA, CHANG-XING; WU, S. S.; ZENG, ZHAO-BANG
- Abstract
Most current linkage analyses assume identical fractions of meiotic recombination between homologous marker loci of the two sexes. This assumption is not realistic, because considerable sex-related differences have been observed in recombination fraction. In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular markers segregating differently in a full-sib family derived from two heterozygous parents. The asymptotic variances of the estimates of linkage specifically for each of the parents are evaluated using a numerical analysis based on information functions. This approach will have important implications for precise gene mapping based on sex-specific linkage maps.
- Publication
Genetics Research, 2002, Vol 79, Issue 1, p85
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672301005389