We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Red cell distribution width improves the prediction of prognosis after transcatheter aortic valve implantation.
- Authors
Collas, Valérie M.; Paelinck, Bernard P.; Rodrigus, Inez E.; Vrints, Christiaan J.; Van Craenenbroeck, Emeline M.; Bosmans, Johan M.
- Abstract
OBJECTIVES: The aim of this study was to determine if red cell distribution width (RDW) could improve the prediction of prognosis after transcatheter aortic valve implantation (TAVI). METHODS: In this single-centre study, 197 consecutive patients underwent TAVI (median age 82 (77-86), 46.2% men). Normal RDW at baseline was defined as ≤15.5%, elevated RDW at baseline was defined as >15.5%. Ouctomes according to the Valve Academic Research Consortium 2 and survival up to one year were compared between these groups. RESULTS: Compared with the patients with RDW ≤15.5% (n = 168), those with RDW >15.5% (n = 29) had a higher Society of Thoracic Surgeon (STS) score (7.2 vs 5.0%, P = 0.041), higher systolic pulmonary arterial pressure (50 vs 41 mmHg, P = 0.021) and lower haemoglobin (11.5 vs 12.4 mg/dl, P = 0.003). Patients with RDW >15.5% developed significantly more adverse events after TAVI (major vascular complications: 10.3 vs 1.8%, P = 0.042; aortic regurgitation grade II–IV: 50.0 vs 18.0%, P = 0.001) and survival up to 1 year was significantly lower (85.6 vs 65.2%, log-rank: P = 0.007). In addition, RDW >15.5% at baseline was the most significant predictor for mortality (hazard ratio: 2.701 (1.279–5.704), P = 0.009), even when the STS score was added to the model [RDW >15.5%: hazard ratio: 2.276 (1.045–4.954), P = 0.038]. CONCLUSIONS: Elevated RDW is a significant predictor for adverse events and increased 1-year mortality after TAVI. Adding RDW to the classical STS score could be a valuable strategy to improve preoperative risk assessment in potential TAVI candidates.
- Subjects
AORTIC valve transplantation; ERYTHROCYTES; ADVERSE health care events; CATHETERIZATION; SURVIVAL analysis (Biometry); PREOPERATIVE period
- Publication
European Journal of Cardio-Thoracic Surgery, 2016, Vol 49, Issue 2, p471
- ISSN
1010-7940
- Publication type
Article
- DOI
10.1093/ejcts/ezv152