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- Title
Brain-Derived Neurotrophic Factor Inhibits Calcium Channel Activation, Exocytosis, and Endocytosis at a Central Nerve Terminal.
- Authors
Baydyuk, Maryna; Xin-Sheng Wu; Liming He; Ling-Gang Wu
- Abstract
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic function and plasticity and plays important roles in neuronal development, survival, and brain disorders. Despite such diverse and important roles, how BDNF, or more generally speaking, neurotrophins affect synapses, particularly nerve terminals, remains unclear. By measuring calcium currents and membrane capacitance during depolarization at a large mammalian central nerve terminal, the rat calyx of Held, we report for the first time that BDNF slows down calcium channel activation, including P/Q-type channels, and inhibits exocytosis induced by brief depolarization or single action potentials, inhibits slow and rapid endocytosis, and inhibits vesicle mobilization to the readily releasable pool. These presynaptic mechanisms may contribute to the important roles of BDNF in regulating synapses and neuronal circuits and suggest that regulation of presynaptic calcium channels, exocytosis, and endocytosis are potential mechanisms by which neurotrophins achieve diverse neuronal functions.
- Subjects
BRAIN-derived neurotrophic factor; CALCIUM channel inhibition; EXOCYTOSIS; ENDOCYTOSIS; NERVE endings; SYNAPSES; NEUROPLASTICITY; PHYSIOLOGY
- Publication
Journal of Neuroscience, 2015, Vol 35, Issue 11, p4676
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2695-14.2015