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- Title
The lactose system in Klebsiella aerogenes V9A: 4. A comparison of the lac operons of Klebsiella and Escherichia coli.
- Authors
Reeve, E. C. R.; Braithwaite, J. A.
- Abstract
Klebsiella aerogenes V9A contains two lac operons, one chromosomal and one borne by the Lac plasmid, FKlac. It is shown that the plasmid Lac repressor resembles that of Esherichia coli in that it represses the E. coli operon but is inactivated by melibiose. In contrast, the chromosomal Lac repressor of V9A is unable to repress the E. coli operon or the FKlac operon, but is converted into an active repressor of both these operons on becoming bound to melibiose. The chromosomal Lac repressor is able to repress its own operon whether or not it is bound to melibiose, but is inactivated by isopropyl-β-D-thiogalactoside. These results support the hypothesis that the Klebsiella Lac plasmid was derived from an ancestral E. coli chromosome.
- Publication
Genetics Research, 1974, Vol 24, Issue 3, p323
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300015329