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- Title
The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia.
- Authors
Franco, Rendrik F.; Simões, Belinda P.; Tone, Luiz G.; Gabellini, Sérgio M.; Zago, Marco A.; Falcão, Roberto P.
- Abstract
We have determined the prevalence of methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C in 71 children (<= 15 years) with acute lymphoblastic leukaemia (ALL) and in 71 control subjects. Odds ratio (OR) for ALL linked to MTHFR C677T was 0·4 (95% CI 0·2–0·8); for heterozygotes it was 0·5 (95% CI 0·2–0·9) and for homozygotes it was 0·3 (95%CI 0·09–0·8). MTHFR A1298C yielded an overall OR for ALL of 1·3 (95% CI: 0·7–2·6); for heterozygotes it was 1·3 (95% CI: 0·7–7·6) and for homozygotes it was 2·8 (95% CI 0·5–15·6). In conclusion, MTHFR C677T was linked to a significant 2·4-fold decreased risk of developing childhood ALL, whereas MTHFR A1298C did not significantly affect the risk of ALL in our population.
- Subjects
LYMPHOBLASTIC leukemia; GENETIC polymorphisms; FOLIC acid; METABOLISM
- Publication
British Journal of Haematology, 2001, Vol 115, Issue 3, p616
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2001.03140.x