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- Title
Bone marrow involvement in Whipple's disease: rarely reported, but really rare?
- Authors
Walter, Roland; Bachmann, Stefano P.; Schaffner, Andreas; Rüegg, Regula; Schoedon, Gabriele
- Abstract
Infection with Tropheryma whippelii, the causative agent of Whipple's disease, involves nearly every organ. Involvement of bone marrow may be an overlooked area of Whipple's disease. We report a case of lymphoma-like Whipple's disease with bone marrow involvement together with a brief review of the literature on this topic. Despite minimal documentation, bone marrow may be commonly involved in Whipple's disease and, although not specific, diastase-resistant periodic acid-Schiff (PAS)-positive macrophages in bone marrow may offer an important clue to diagnosis using PAS histology of upper endoscopic biopsies, polymerase chain reaction or electron microscopy.
- Subjects
WHIPPLE'S disease; BONE marrow; PERIODIC acid
- Publication
British Journal of Haematology, 2001, Vol 112, Issue 3, p677
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2001.02648.x