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- Title
Increased Acylation Stimulating Protein Concentrations in Nonalcoholic Fatty Liver Disease are Associated with Insulin Resistance.
- Authors
Yesilova, Zeki; Ozata, Metin; Oktenli, Cagatay; Bagci, Sait; Ozcan, Ayhan; Sanisoglu, S. Yavuz; Uygun, Ahmet; Yaman, Halil; Karaeren, Necmettin; Dagalp, Kemal
- Abstract
OBJECTIVES: As acylation stimulating protein (ASP) acts on adipocytes mainly as a paracrine factor to increase triglyceride synthesis and storage; hypothetically, it may play a similar role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD).METHODS: Forty-six male patients with NAFLD (group A), age-matched 30 male patients with chronic viral hepatitis (group B) and 30 age-matched and body mass index (BMI)-matched healthy male subjects were enrolled in the study.RESULTS: Among the NAFLD patients, 10 patients (24.4%) had simple steatosis and 36 patients (69.6%) had nonalcoholic steatohepatitis (NASH). The mean levels of ASP, complement 3, insulin, C-peptide, HOMA-IR, triglyceride, and very low-density lipoprotein (VLDL) were significantly higher in group A patients than both controls and group B. ASP levels correlated significantly in a positive manner with BMI, insulin, and HOMA-IR.CONCLUSIONS: Dysregulation of the ASP pathway may have important metabolic consequences in NASH and is associated with insulin resistance.(Am J Gastroenterol 2005;100:1–8)
- Subjects
FATTY liver; FATTY degeneration; LIVER diseases; INSULIN resistance; FAT cells; LOW density lipoproteins; ACYLATION; CHEMICAL reactions
- Publication
American Journal of Gastroenterology (Springer Nature), 2005, Vol 100, Issue 4, p842
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.2005.40838.x