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- Title
Thyroid and Celiac Disease: Clinical, Serological, and Echographic Study.
- Authors
Velluzi, F.; Caradonna, A.; Boy, M. F.; Pinna, M. A.; Cabula, R.; Lai, M. A.; Piras, E.; Corda, G.; Mossa, P.; Atzeni, F.; Loviselli, A.; Usai, P.; Mariotti, S.
- Abstract
Objective: We sought to reevaluate the prevalence of thyroid dysfunction and thyroid autoimmunity in 47 patients with celiac disease; 91 healthy subjects were studied as controls. Both patients and controls were from Sardinia, Italy. Methods: Diagnosis of celiac disease was made on the basis of clinical history, presence of positive antigliadin IgA (AGA-A) and IgG (AGA-G) antibodies, antireticulin antibodies (ARA), antiendomysium antibodies (EMA), and was confirmed by jejunal biopsy. HLA class II typing for DQB1 and DQA1 alleles was performed in 36/47 celiac patients. Thyroid was evaluated by palpation and echography; serum free thyroid hormones (FT4, FT3), thyrotropic hormone (TSH), and antithyroid peroxidase autoantibodies (anti-TPO) were assayed by radioimmunoassays. Results: The prevalence of anti-TPO was higher in celiac patients (29.7 %) than in healthy controls (9.6%) (p < 0.001) and thyroid echography frequently displayed (42.5%) a hypoechogenic pattern. Five anti-TPO-positive celiac patients were hypothyroid (two overt, three subclinical). A higher but not significantly different prevalence of anti-TPO (3/7 = 42.8%) was found in celiac patients displaying the DQBI*0502 genotype, when compared with the remaining patients (8/29 = 27.6%). Conclusions: An elevated prevalence of clinical and subclinical autoimmune thyroid autoimmunity was found in Sardinian celiac patients, especially in those displaying the DQBI*0502 genotype; this finding could be related to a particular genetic background of the Sardinian population.
- Subjects
ITALY; THYROID diseases; AUTOIMMUNITY; PATIENTS; CELIAC disease; PALPATION; ULTRASONIC imaging
- Publication
American Journal of Gastroenterology (Springer Nature), 1998, Vol 93, Issue 6, p976
- ISSN
0002-9270
- Publication type
Article