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- Title
Lessons in waste management: Deciphering the dual role of Crustacean Rh1 protein in ammonia and CO<sub>2</sub> excretion.
- Authors
Clifford, Alexander M.
- Abstract
The article in Acta Physiologica explores the dual role of the Crustacean Rh1 protein in ammonia and CO2 excretion in the European green crab. The regulation of ammonia and CO2 is crucial for homeostasis in aquatic organisms, as their accumulation can be detrimental to cellular function. The article discusses the traditional views on NH3/NH4+ transport and the discovery of Rh glycoproteins as ammonia transport facilitators. It also examines the involvement of Rh proteins in CO2 transport and presents the findings of a study on the Crustacean specific isoform Rh1 protein. The study utilizes various techniques to investigate the dual function of Rh1, including cloning, mutagenesis, and expression experiments. The authors demonstrate the transport capacity of Rh1 for both ammonia and CO2 and observe the expression patterns of CmRh1 in the gills of the green crab. The article suggests the existence of subcellular reorganization and a potential sensing mechanism for NH3 and/or NH4+ in response to high environmental ammonia. It also highlights the need for further research to understand the mechanisms of Rh protein-mediated CO2 transport and its universality across different species. Overall, the study contributes to our understanding of Rh glycoproteins and their role in waste management.
- Subjects
WASTE management; AMMONIA; EXCRETION; CRUSTACEA; RENAL tubular transport disorders; PROTEINS; ATP-binding cassette transporters
- Publication
Acta Physiologica, 2024, Vol 240, Issue 2, p1
- ISSN
1748-1708
- Publication type
Article
- DOI
10.1111/apha.14079