We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lack of Association Between Inherited Thrombophilic Risk Factors and Idiopathic Sudden Sensorineural Hearing Loss in Italian Patients.
- Authors
Cadoni, Gabriella; Scipione, Simona; Rocca, Bianca; Agostino, Stefania; La Greca, Carmelo; Bonvissuto, Davide; Paludetti, Gaetano
- Abstract
Objectives: We investigated the presence of congenital thrombophilic risk factors in a population of consecutive Italian patients affected by idiopathic sudden sensorineural hearing loss (SSNHL). Methods: We investigated 48 patients with idiopathic SSNHL for the presence of congenital thrombophilic risk factors. The factor V Leiden G1691A, the prothrombin G20210A allele, and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes were investigated. Allele frequencies and genotype distribution of all factors found in patients were compared to those of 48 healthy subjects of the same ethnic background by χ² and odds-ratio analysis. Odds ratios and 95% confidence intervals were calculated for allele and genotype frequencies of all thrombophilia variants. Statistical significance was accepted with a p value of less than .05. We also performed the following blood tests: hemacytometric analysis including platelet count, prothrombin time, activated partial thromboplastin time, fibrinogen, erythrocyte sedimentation rate, C-reactive protein, protein S, protein C, antithrombin 111, and activated protein C resistance. Results: In our series, we did not find an association between SSNHL and abnormal levels of antithrombin 111, protein C, protein S, D-dimer, or fibrinogen; activated protein C resistance; or factor V G1691A, prothrombin G20210A, or MTHFR C677T mutations. Conclusions: At present, the few studies regarding genetic polymorphisms of congenital thrombophilic factors in SSNHL are not conclusive. According to our data, factor V G1691A, prothrombin G20210A, and MTHFR C677T variants should be not considered risk factors for SSNHL. Further large prospective studies are needed to provide currently lacking information and to improve our knowledge in the field before we recommend the determination of genetic polymorphism in SSNHL as routine practice.
- Subjects
ITALY; SENSORINEURAL hearing loss; BLOOD diseases; GENETIC disorders; FIBRINOGEN; BLOOD sedimentation
- Publication
Annals of Otology, Rhinology & Laryngology, 2006, Vol 115, Issue 3, p195
- ISSN
0003-4894
- Publication type
Article
- DOI
10.1177/000348940611500307