We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association between HLA alleles and HAM/TSP in individuals infected with HTLV-1.
- Authors
Treviño, Ana; Vicario, Jose; Lopez, Mariola; Parra, Patricia; Benito, Rafael; Ortiz de Lejarazu, Raul; Ramos, Jose; Romero, Jorge; Mendoza, Carmen; Soriano, Vincent
- Abstract
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) develops in less than 5 % of HTLV-1 carriers. It is unclear which factors trigger the development of disease. The aim of this study was to explore the influence of HLA alleles on the development of HAM/TSP. A total of 40 HTLV-1-infected individuals belonging to the Spanish HTLV-1 cohort were examined. HTLV-1 proviral load was measured by real-time polymerase chain reaction. HLA class I (A, B, C) and class II (DRB1, DQB1) alleles were genotyped using the bead array technology. Median HTLV-1 proviral load in 12 HAM/TSP patients was greater than in 28 asymptomatic carriers (637 vs. 71 copies per 10 peripheral blood mononuclear cells; p = 0.006). Moreover, HAM/TSP was significantly associated with HLA-B*07 and HLA-DRB1*01:01 ( p = 0.039). Interestingly, individuals with these HLA alleles had greater HTLV-1 proviral load than asymptomatic carriers ( p = 0.036). In summary, HLA testing should be considered in asymptomatic HTLV-1 individuals and close monitoring of HTLV-1 proviral load along with periodic neurological evaluations should be prioritized in HLA-DRB1*01:01 and HLA-B*07 carriers.
- Subjects
HTLV-I; PARAPARESIS; VIRAL load; POLYMERASE chain reaction; ALLELES
- Publication
Journal of Neurology, 2013, Vol 260, Issue 10, p2551
- ISSN
0340-5354
- Publication type
Article
- DOI
10.1007/s00415-013-7014-z