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- Title
The effect of Krill oil supplementation on blood glucose levels in alloxan-induced hyperglycemic rats.
- Authors
Nurmadilla, Nesyana; Nugraha Pratiwi, Anastasia; Bamahry, Aryanti; Sulvita, Nevi; Sodiqah, Yani
- Abstract
Introduction: Hyperglycemia is a condition associated with long-term complications and damage of multiple susceptible organs, including the eye, kidney, nerve, and heart. Krill oil contains astaxanthin, which is an antioxidant that acts to fight free radicals. The study aims to determine the effect of krill oil supplementation on blood glucose levels of alloxaninduced hyperglycemic rats. Methods: This was an experimental pre- and post-control group. Twentyfour hyperglycemic rats were randomly assigned into four groups. Each group received a different intervention (placebo, glibenclamide, fish oil, and krill oil) for 14 days. Blood glucose measurements were carried out four times (after acclimatization, after alloxan induction, day 7 of intervention, and day 14 of intervention). Results: The average level of blood glucose levels in each group decreased after 14 days of intervention were as follows: placebo group (222.16 mg/dL), glibenclamide group (99.33 mg/dL), fish oil group (114.33 mg/dL), and krill oil group (99 mg/dL). There was a statistically significant difference in the mean reduction of blood glucose levels between groups after seven days of intervention (F (3.20) = 4.513, p=0.014) and 14 days of supplementation (F (3.20) = 19.794, p<0.001). Post-hoc comparisons indicated that the mean reduction of blood glucose levels for the krill oil group was significantly different from all other groups after 7 days and 14 days of intervention. Conclusion: Supplementation of krill oil for 7–14 days can significantly reduce blood glucose levels in hyperglycemic rats.
- Subjects
KRILL oil; BLOOD sugar; ALLOXAN diabetes; HYPERGLYCEMIA; FISH oils
- Publication
Gaceta Médica de Caracas, 2021, Vol 129, Issue 4, p871
- ISSN
0367-4762
- Publication type
Article
- DOI
10.47307/GMC.2021.129.4.6