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- Title
The gingiva contains leptin and leptin receptor in health and disease.
- Authors
Yetkin Ay, Zuhal; Kırzıoğlu, F.; Öztürk Tonguç, Mine; Sütçü, Recep; Kapucuoğlu, Nilgün
- Abstract
The presence of leptin (OB) and soluble OB receptor (s-OB-R) in gingival tissue extract and gingival crevicular fluid has led the studies investigating the relationship between OB and periodontal diseases. This study aims to investigate the levels of OB and s-OB-R in serum and their presence in gingiva of healthy controls (HC), gingivitis (G), aggressive periodontitis (AP), and chronic periodontitis (CP) patients; and whether correlations exist between clinical and serum parameters, OB and s-OB-R. Seventy-seven subjects [HC ( n = 20), G ( n = 20), CP ( n = 21), and AP ( n = 16)] were included in this study. After the clinical periodontal parameter recordings and venous blood sampling, gingival tissues obtained. Serum parameters' levels determined with enzyme linked immune sorbent assay; and OB and OB-R in gingiva immunohistochemically. No significant differences were observed regarding the serum parameters [high sensitivity C-reactive protein (hs-CRP), lipids, OB, and s-OB-R] when the groups were compared ( P > 0.0125). The serum OB has positive correlations with hs-CRP in the G group ( P < 0.05), and s-OB-R has presented significant negative correlations with BOP in HC group ( P < 0.05), with hs-CRP in G ( P < 0.05) and AP groups ( P < 0.05). The positive correlations were observed between the serum OB and HDL and body mass index in the CP group ( P < 0.05). In all of the tissue samples of all groups, there was positive OB and OB-R immunoreactivity in the gingival epithelium. The gingival tissues contain both OB and OB-R. The serum levels of OB and s-OB-R do not vary between patients and with different periodontal conditions.
- Subjects
LEPTIN; PERIODONTAL disease; PERIODONTITIS; C-reactive protein; ENZYME-linked immunosorbent assay
- Publication
Odontology, 2012, Vol 100, Issue 2, p222
- ISSN
1618-1247
- Publication type
Article
- DOI
10.1007/s10266-011-0043-0