We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Atroposelective Chan–Evans–Lam Amination.
- Authors
Thönnißen, Vinzenz; Westphäling, Johannes; Atodiresei, Iuliana L.; Patureau, Frederic W.
- Abstract
The synthetic control of atropoisomerism along C−N bonds is a major challenge, and methods that allow C−N atroposelective bond formation are rare. This is a problem because each atropoisomer can feature starkly differentiated biological properties. Yet, among the three most practical and applicable classical amination methods available: 1) the Cu‐catalyzed Ullmann–Goldberg reaction, 2) the Pd‐catalyzed Buchwald–Hartwig reaction, and 3) the Cu‐catalyzed Chan–Evans–Lam reaction, none has truly been rendered atroposelective at the newly formed C−N bond. The first ever Chan–Evans–Lam atroposelective amination is herein described with a simple copper catalyst and newly designed PyrOx chiral ligand. This method should find important applications in asymmetric synthesis, in particular for medicinal chemistry.
- Subjects
AMINATION; COPPER catalysts; PHARMACEUTICAL chemistry; ENANTIOSELECTIVE catalysis
- Publication
Chemistry - A European Journal, 2024, Vol 30, Issue 16, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202304378