We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Does a computer-aided detection algorithm in a second read paradigm enhance the performance of experienced computed tomography colonography readers in a population of increased risk?
- Authors
de Vries AH; Jensch S; Liedenbaum MH; Florie J; Nio CY; Truyen R; Bipat S; Dekker E; Fockens P; Baak LC; Stoker J; de Vries, Ayso H; Jensch, Sebastiaan; Liedenbaum, Marjolein H; Florie, Jasper; Nio, Chung Y; Truyen, Roel; Bipat, Shandra; Dekker, Evelien; Fockens, Paul
- Abstract
We prospectively determined whether computer-aided detection (CAD) could improve the performance characteristics of computed tomography colonography (CTC) in a population of increased risk for colorectal cancer. Therefore, we included 170 consecutive patients that underwent both CTC and colonoscopy. All findings >or=6 mm were evaluated at colonoscopy by segmental unblinding. We determined per-patient sensitivity and specificity for polyps >or=6 mm and >or=10 mm without and with computer-aided detection (CAD). The McNemar test was used for comparison the results without and with CAD. Unblinded colonoscopy detected 50 patients with lesions >or=6 mm and 25 patients with lesions >or=10 mm. Sensitivity of CTC without CAD for these size categories was 80% (40/50, 95% CI: 69-81%) and 64% (16/25, 95% CI: 45-83%), respectively. CTC with CAD detected one additional patient with a lesion >or=6 mm and two with a lesion >or=10 mm, resulting in a sensitivity of 82% (41/50, 95% CI: 71-93%) (p = 0.50) and 72% (18/25, 95% CI: 54-90%) (p = 1.0), respectively. Specificity without CAD for polyps >or=6 mm and >or=10 mm was 84% (101/120, 95% CI: 78-91%) and 94% (136/145, 95% CI: 90-98%), respectively. With CAD, the specificity remained (nearly) unchanged: 83% (99/120, 95% CI: 76-89%) and 94% (136/145, 95% CI: 90-98%), respectively. Thus, although CTC with CAD detected a few more patients than CTC without CAD, it had no statistically significant positive influence on CTC performance.
- Publication
European Radiology, 2009, Vol 19, Issue 4, p941
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-008-1215-3