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- Title
Synthesis of anti-HIV nucleoside conjugates with lipophilic diol compounds.
- Authors
Tuchnaya, O. A.; Elizarova, S. N.; Sharikova, S. A.; Shastina, N. S.; Stepanov, A. E.; Yurkevich, A. M.; Shvets, V. I.
- Abstract
Synthesis of anti-HIV nucleoside lipophilic derivatives with diol compounds in which two antiviral pharmacophore residues are linked by a single hydrophobic fragment is described. It is suggested to use 2,3,4,5-tetra-O-benzyl- D, L-iditol and 1,12-dodecanediol as hydrophobic transport systems. Succinic and phosphodiester fragments were used for binding molecular units in the target conjugates.
- Subjects
HIV; NUCLEOSIDES; BIOSYNTHESIS; ANTIVIRAL agents; DRUG lipophilicity; PHOSPHODIESTERS
- Publication
Pharmaceutical Chemistry Journal, 2006, Vol 40, Issue 5, p276
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-006-0108-5