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- Title
Molecular epidemiology and evolution of resistance to quinolones in Escherichia coli after prolonged administration of ciprofloxacin in patients with prostatitis.
- Authors
Horcajada, Juan P.; Vila, Jordi; Moreno-Martínez, Antonio; Ruiz, Joaquim; Martínez, Jose Antonio; Sánchez, Miquel; Soriano, Eladio; Mensa, Josep; Moreno-Martínez, Antonio; Martínez, Jose Antonio; Sánchez, Miquel
- Abstract
The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied. In 11 of 23 patients, from whom only quinolone-susceptible E. coli was isolated before treatment, quinolone-resistant strains, genetically distinct from the quinolone-susceptible ones, predominated during and just after therapy. Two months after treatment, these were completely displaced by quinolone-susceptible E. coli, genetically distinct from the E. coli isolated before and during therapy. Hence, during ciprofloxacin therapy, half of the patients were transiently colonized with new, quinolone-resistant strains of E. coli.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2002, Vol 49, Issue 1, p55
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/49.1.55