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- Title
Relationship between TG/HDL-C Ratio and TyG Index with Chronic Inflammation in People with Prediabetes: A Cross-Sectional Study.
- Authors
Fahly, Rizal; Adam, Fabiola M. S.; Rasyid, Haerani; Aman, Andi Makbul; Bakri, Syakib; Mappangara, Idar; Zainuddin, Andi Alfian
- Abstract
Objective: Prediabetes is an insulin resistance (IR) condition. The triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and triglyceride-glucose (TyG) index were associated with prediabetes and IR condition which are related to cardiovascular disease (CVD). High sensitive-CRP (hs-CRP) is a marker of inflammation that is closely related to CVD. The aim of this study is to determine the correlation between TG/HDL-C ratio and TyG index with hs-CRP as a marker of chronic inflammation in impaired fasting glucose (IFG). Material and methods: An observational study with a cross-sectional approach involved 92 people with prediabetes in Makassar City, Indonesia, in February 2022. Research subjects were participants of Makassar Lipid and Diabetes Study aged 18-70 years who met inclusion criteria. Triglyceride, HDL-C, fasting plasma glucose (FPG), and hs-CRP were examined. Level of hs-CRP > 3-10 mg/L is a high risk of CVD. Prediabetes is defined by fasting plasma glucose of 100-125 mg/dL. Statistical analysis was performed using Kruskal-Wallis and Chi-Square tests. Results: The mean TG/HDL-C ratio was 4.88, the mean TyG index was 4.92, and the mean hs-CRP level was 4.53 ± 2.91 mg/L. There was no statistically significant relationship between TG/HDL-C ratio and high hs-CRP levels in people with prediabetes (p = 0.45). There was no statistically significant relationship between the TyG index and high hs-CRP levels in people with prediabetes (p = 1.00). Conclusions: There is no statistically significant relationship between TG/HDL-C ratio or TyG index and hs-CRP in people with prediabetes defined by IFG.
- Subjects
INDONESIA; INFLAMMATION; PREDIABETIC state; INSULIN resistance; CARDIOVASCULAR diseases
- Publication
Clinical Diabetology, 2022, Vol 11, Issue 5, p321
- ISSN
2450-7458
- Publication type
Article
- DOI
10.5603/DK.a2022.0047