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- Title
Association of PCOS with offspring morbidity: a longitudinal cohort study.
- Authors
Wei, Shu Qin; Bilodeau-Bertrand, Marianne; Auger, Nathalie
- Abstract
<bold>Study Question: </bold>Do children whose mothers have polycystic ovary syndrome (PCOS) have an increased risk of morbidity?<bold>Summary Answer: </bold>Maternal PCOS is associated with an increased risk of infection, allergy and other childhood morbidity.<bold>What Is Known Already: </bold>PCOS is associated with higher rates of gestational diabetes, pre-eclampsia and preterm delivery, but the long-term impact on child health is poorly understood.<bold>Study Design, Size, Duration: </bold>We conducted a retrospective longitudinal cohort study of 1 038 375 children in Quebec between 2006 and 2020.<bold>Participants/materials, Setting, Methods: </bold>We included 7160 children whose mothers had PCOS and 1 031 215 unexposed children. Outcomes included child hospitalization for infectious, allergic, malignant and other diseases before 13 years of age. We estimated hazard ratios (HRs) and 95% CI for the association of PCOS with childhood morbidity in adjusted Cox proportional hazards regression models.<bold>Main Results and the Role Of Chance: </bold>Children exposed to PCOS were hospitalized at a rate of 68.9 (95% CI 66.2-71.8) per 1000 person-years, whereas unexposed children were hospitalized at a rate of 45.3 (95% CI 45.1-45.5) per 1000 person-years. Compared with no exposure, maternal PCOS was associated with 1.32 times the risk of any childhood hospitalization (95% CI 1.26-1.40), 1.31 times the risk of infectious disease hospitalization (95% CI 1.25-1.38) and 1.47 times the risk of allergy-related hospitalization (95% CI 1.31-1.66). Risk of hospitalization was also elevated for childhood metabolic (HR 1.59, 95% CI 1.16-2.18), gastrointestinal (HR 1.72, 95% CI 1.53-1.92), central nervous system (HR 1.74, 95% CI 1.46-2.07) and otologic disorders (HR 1.34, 95% CI 1.26-1.43). Subgroup analyses suggested that there was little difference in the association of PCOS with hospitalization among boys (HR 1.31, 95% CI 1.24-1.39) and girls (HR 1.34, 95% CI 1.26-1.43).<bold>Limitations, Reasons For Caution: </bold>We analyzed severe childhood morbidity requiring hospitalization, not mild diseases treated in ambulatory clinics. We lacked data on ethnicity, education and physical activity, and cannot rule out residual confounding.<bold>Wider Implications Of the Findings: </bold>Our findings suggest that maternal PCOS is associated with an increased risk of childhood morbidity.<bold>Study Funding/competing Interest(s): </bold>This study was supported by grant PJT-162300 from the Canadian Institutes of Health Research. N.A. acknowledges a career award from the Fonds de recherche du Québec-Santé (296785). The authors declare no competing interests.<bold>Trial Registration Number: </bold>N/A.
- Subjects
QUEBEC (Quebec); CANADA; NARCOTICS Anonymous; ECLAMPSIA; POLYCYSTIC ovary syndrome; PROPORTIONAL hazards models; LONGITUDINAL method; COHORT analysis; HOSPITAL care of children; DISEASES; RETROSPECTIVE studies; IMPACT of Event Scale; QUESTIONNAIRES; RESEARCH funding; ALLERGIES; DISEASE complications
- Publication
Human Reproduction, 2022, Vol 37, Issue 9, p2135
- ISSN
0268-1161
- Publication type
journal article
- DOI
10.1093/humrep/deac154