We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Occurrence of placental abruption in relatives.
- Authors
Rasmussen, S.; Irgens, L. M.
- Abstract
Objective The aim of this study was to assess the recurrence of placental abruption by severity, comparing the risk in a woman with that of recurrence in her sister and in the partner of her brother. Design Prospective observational study. Setting General population. Population Population-based study based on records of pregnancies from the Medical Birth Registry of Norway; 377 902 sisters with 767 395 pregnancies, 168 142 families incorporating 2–10 sisters, and 346 385 brothers with 717 604 pregnancies in their partners were identified. Methods Placental abruption with preterm birth, birthweight below 2500 g or perinatal death was defined as severe, other cases as mild. Because of the nested family data structure, multilevel multivariate regression was used. Main outcome measures Placental abruption (severe and mild). Results Adjusted odds ratios of recurrence of mild and severe abruption were 6.5 (1.7%) and 11.5 (3.8%), respectively, compared with risks of 0.2 and 0.3% in the total population. After a severe abruption, odds ratios in her sisters were 1.7–2.1, whereas mild abruption produced no increased recurrence in sisters. The estimated heritability between sisters of severe abruption was 16%. No excess rate of abruption was observed between sisters and brothers’ partners, between brothers’ partners, or from brothers’ partners to sisters. The odds ratios for a third abruption after a second abruption and a second severe abruption were 38.7 (19%) and 50.1 (24%), respectively. Conclusions The recurrence risk of placental abruption in the same woman was higher after severe than mild abruption. Severe abruption was associated with a two-fold risk in sisters. Pregnancies following a second abruption should be considered very high risk.
- Subjects
PLACENTA; WOMEN; PREGNANCY; FETAL development; MULTIVARIATE analysis
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2009, Vol 116, Issue 5, p693
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/j.1471-0528.2008.02064.x